B Cell
B Cell
The responses of B cells to an injected foreign particle is measured mainly by analyzing the specific antibody production in a humoral immune response.
The complement mediated hemolysis test is based on the ability of serum antibodies to form complement-activating immune complexes upon union with their specific antigens.
The Cunningham Plaque Assay (hemolytic assays in general) was used as a method of directly detecting and evaluating the IgM response. Ig secreted by mouse plasma cells, to sheep red blood cells (sRBCs) and assess potential modulation of the humoral immune response.
Diffuse Large B Cell Lymphoma is an aggressive non-hodgkin’s lymphoma, NHL. Diffuse Large B Cell Lymphoma often presents as a gastrointestinal tumour with symptoms reflecting its location.
Hemagglutination is an assay based on the ability of antibodies binding to their antigen to alter the physical state of the bound antigen.
IgG is the class of immunoglobulin that is most abundant. It is found in the plasma and is characterized by gamma heavy chains. Moreover, IgG is a monomeric immunoglobulin siotype, divided in humans into subclasses IgG 1,2,3 and 4.
Non-Hodgkin’s Lymphoma is a difficult disease group to understand. It is mainly a malignancy of lymphoid cells which are usually from lymph nodes, however, non nodal sites may be the site of origination, such as the gastrointestinal tract or liver. The disease then may spread to other non-lymphoid areas. These diseases are much harder to diagnosis, and patients once found to have disease, it is already widespread. The disease increases with age.
The Mancini Test, also known as the radial immunodiffusion test, is performed using agar with added anti-BSA, to set of predetermined BSA solution concentrations and also to determine the concentration of an unknown sample.
Opsonization is the lateration of a pathogens or particles surface, either by the attachment of complement or antibodies specific for the antigen, so that it can be ingested (phagocytosed) by phagocytes, macrophages and neutrophils.
Proteolytic enzymes (proteases) cleave polypeptide sequences. These enzymes have been intensely used to elucidate through dissection, the structure of antibody molecules.
Plasma cells play a critical role in the adaptive immune response.
Capable of detecting and quantifying antigens, the radial immunodiffusion is a technique in which antibody is incorporated into an agar gel, followed by the addition of antigen into formed wells of the antibody-containing agar.
Two test tubes were prepared, one with a 5 mm depth of undiluted, normal rabbit serum (control) and another tube contained a 5 mm depth of un-diluted anti-BSA.